SHED vs SynergyRX
SHED vs SynergyRX for GLP-1 in 2026 — pricing, medications, shipping and credentials compared side by side.
Educational, not medical advice. This page explains GLP-1 medications in general terms. Only a licensed clinician who knows your history can decide what's right for you.
Our top choice
9.2/10 vs 9.0/10
SHED is our pick for most people here — sHED is our pick in this matchup — a strong first-month discount on compounded GLP-1. Consider SynergyRX instead if its strength — hands-on medical supervision at scale — matters more to you. The full reasoning, the numbers, and the cases where SynergyRX is the better call are all below.
View Plan: SHED| At a glance | SHED | SynergyRX |
|---|---|---|
| Starting price | 30% off first month (then plan rate) | Varies (medically supervised plans) |
| Medications | Semaglutide · Tirzepatide | Semaglutide · Tirzepatide |
| Offering | Compounded | Compounded |
| Shipping | Included | Included |
Prices are each provider’s published rate at our last check — confirm the final figure at checkout, as offers change. How we rank
Science-backed GLP-1, 30% off your first month
- 30% off your first month
- Compounded semaglutide and tirzepatide
- Multiple treatment options
Medically supervised GLP-1, lose 1–2 lbs per week
- Personalized medical supervision
- Trusted by over 50,000 patients
- Featured by leading health publications
The full breakdown
SHED vs SynergyRX: a closer look at each
SHED and SynergyRX are both telehealth GLP-1 programs, but they differ on price, medications, shipping and how you pay. Here's the side-by-side, with the numbers, so you can pick the right one.
Best for: Strong intro discount
Choose SHED if…
you want SHED's edge — a strong first-month discount on compounded GLP-1.
Best for: Hands-on medical supervision
Choose SynergyRX if…
you want SynergyRX's edge — hands-on medical supervision at scale.
The money
Cost breakdown
The numbers that actually decide it, side by side.
| | |
|---|---|---|
| Starting price | 30% off first month (then plan rate) | Varies (medically supervised plans) |
| Semaglutide | Compounded (plan-dependent) | Compounded (plan-dependent) |
| Tirzepatide | Compounded (plan-dependent) | Compounded (plan-dependent) |
| Offering | Compounded | Compounded |
| Shipping | Included | Included |
| Insurance | Cash | Cash |
On price, SHED lists Compounded (plan-dependent) for compounded semaglutide and Compounded (plan-dependent) for tirzepatide, while SynergyRX lists Compounded (plan-dependent) and Compounded (plan-dependent). Where prices are published, SHED is the lower-cost option.
Both are cash-pay compounded programs, so the real decision comes down to price, shipping, pharmacy credentials and support rather than the drug itself.
Side by side
Full specs, compared
| | |
|---|---|---|
| Why choose it | A strong first-month discount on compounded GLP-1 | Hands-on medical supervision at scale |
| Watch out for | Confirm the ongoing price after the intro month | Entry pricing isn't published as one flat number |
| Starting price | 30% off first month (then plan rate) | Varies (medically supervised plans) |
| Compounded semaglutide | Compounded (plan-dependent) | Compounded (plan-dependent) |
| Tirzepatide | Compounded (plan-dependent) | Compounded (plan-dependent) |
| GLP-1 + GIP option | Yes — compounded tirzepatide (GLP-1/GIP) | Yes — compounded tirzepatide (GLP-1/GIP) |
| Offering type | Compounded | Compounded |
| New-patient offer | 30% off first month | Varies |
| Billing model | Monthly plan (intro discount month one) | Monthly plans |
| What's included | Medical evaluation, Medication, Shipping | Physician supervision, Medication, Shipping |
| Lab work | Online intake | Online intake |
| Shipping | Included | Included |
| Refills | Monthly refills | Monthly refills |
| States | Most US states | Most US states |
| Pharmacy | US compounding pharmacies | US compounding pharmacies |
| Clinicians | US-licensed prescribers | US-licensed physicians |
| Insurance | Cash | Cash |
| Consultation | Online medical intake | Physician-supervised online |
| Our rating | 9.2 · Excellent | 9.0 · Excellent |
The medicine
Medications & formulations
- SHED: compounded GLP-1. Yes — compounded tirzepatide (GLP-1/GIP)
- SynergyRX: compounded GLP-1. Yes — compounded tirzepatide (GLP-1/GIP)
New to the drugs themselves? Read our plain-language guides to semaglutide, tirzepatide, and the new GLP-1 pills.
The trade-offs
Pros & cons
Pros
- Solid 30%-off intro offer
- Both semaglutide and tirzepatide
- Straightforward online process
Cons
- Ongoing price after intro month less transparent
- Compounded only
Pros
- Close medical supervision
- Large, established patient base
- Personalized plans
Cons
- Pricing not published as a flat rate
- Compounded only
What real SHED customers say
1,134 reviews · checked October 2026
Verbatim reviews we captured, including every 1-star one.
“Gao helped me with several issues very quickly. Very personable too. And I love Shed too”
BAG
US
“Your communications are excellent! Ethan was quick to reply to my request for clarifications. Recommended!”
BB
US
“The app & chat function are a little clunky, but improving. Once you start emailing (not chatting) with a real person, Savannah was the best. Another agent told me I was SOL, but Savannah went a step further and resolved my issue.”
R M
US
“It was a nice personal touch to receive a phone call from a real person instead of a robo call. Thank you for the kind follow up.”
Maria M.
US
Reviews are individual experiences quoted verbatim from public Trustpilotprofiles, names shortened; any weight-loss result mentioned is one person’s and is not typical — results vary. We don’t edit or curate them to flatter our pick.
Head to head
Where each one wins
We don't tally a single winner — that hides the trade-offs. Here's who leads on each dimension, and why.
Neither publishes a flat semaglutide price — confirm both directly.
SHED offers compounded; SynergyRX offers compounded.
SHED: Included. SynergyRX: Included.
Comparable pharmacy disclosures.
Both are primarily cash-pay for compounded GLP-1.
Pick fast
Match it to your priority
Find your top priority, see which program we'd point you to.
If your priority is the lowest published price
If your priority is the best shipping
If your priority is our overall pick
Questions
SHED vs SynergyRX: common questions
The bottom line
SHED is our pick in this matchup — a strong first-month discount on compounded GLP-1. Choose SynergyRX only if its strength (hands-on medical supervision at scale) matters more to you than price and our overall rating.
How we compare — and how to read this
We weigh the factors that actually change a patient’s experience: real price (and whether it’s compounded or branded), the medications and formulations on offer, shipping, pharmacy accreditation and the clinician model, insurance stance, and commitment. We name a top pick for most people, then lay the trade-offs out in full so you can override it when your priorities or insurance point the other way. Pricing is provider-reported and moves often — and compounded-drug availability shifts with FDA shortage status — so confirm the current details on the provider’s own site before enrolling. Affiliate relationships never change a program’s placement. This page is educational, not medical advice; see our disclaimer.