Top GLP-1Independent GLP-1 reviews & research

Yucca vs DirectMeds

Yucca vs DirectMeds for GLP-1 in 2026 — pricing, medications, shipping and credentials compared side by side.

TGBy the Top GLP-1 Editorial Team· Reviewed 2026-10-05· Cites FDA & NEJM· Not medical advice
21 programs compared Independent — rankings aren't for saleHow we rank →

Educational, not medical advice. This page explains GLP-1 medications in general terms. Only a licensed clinician who knows your history can decide what's right for you.

Our top choice

8.1/10 vs 8.0/10

Yucca is our pick for most people here — yucca is our pick in this matchup — nationwide 50-state licensing with a low entry price. Consider DirectMeds instead if its strength — fast shipping and a low entry price, no insurance needed — matters more to you. The full reasoning, the numbers, and the cases where DirectMeds is the better call are all below.

View Plan: Yucca
At a glanceYuccaDirectMeds
Starting priceFrom $146/moFrom $147/mo
MedicationsSemaglutide · TirzepatideSemaglutide · Tirzepatide
OfferingCompoundedCompounded
ShippingFree expeditedFree 1–2 day

Prices are each provider’s published rate at our last check — confirm the final figure at checkout, as offers change. How we rank

Yucca logo
Licensed telehealth

GLP-1 plans from $146, licensed in all 50 states

  • Licensed providers in all 50 states
  • Free expedited prescription shipping
  • Trusted by 20,000+ patients
Visit Yucca
VS
DirectMeds logo
4.6 / 5(16,390) Licensed telehealth

GLP-1 plans from $147 with 1–2 day shipping

  • Free shipping in 1–2 days
  • No insurance required
  • Online medical visit included
Visit DirectMeds

The full breakdown

Yucca vs DirectMeds: a closer look at each

Yucca and DirectMeds are both telehealth GLP-1 programs, but they differ on price, medications, shipping and how you pay. Here's the side-by-side, with the numbers, so you can pick the right one.

Yucca logo
OUR PICK
8.1/10#19 of 23· From $146/mo

Best for: All 50 states, low entry price

Choose Yucca if…

you want Yucca's edge — nationwide 50-state licensing with a low entry price.

DirectMeds logo
8.0/10#20 of 23· From $147/mo

Best for: Fast shipping, no insurance needed

Choose DirectMeds if…

you want DirectMeds's edge — fast shipping and a low entry price, no insurance needed.

The money

Cost breakdown

The numbers that actually decide it, side by side.

Yucca
DirectMeds
Starting priceFrom $146/moFrom $147/mo
SemaglutideCompounded (from ~$146/mo)Compounded (from ~$147/mo)
TirzepatideCompounded (plan-dependent)Compounded (plan-dependent)
OfferingCompoundedCompounded
ShippingFree expeditedFree 1–2 day
InsuranceCashCash

On price, Yucca lists Compounded (from ~$146/mo) for compounded semaglutide and Compounded (plan-dependent) for tirzepatide, while DirectMeds lists Compounded (from ~$147/mo) and Compounded (plan-dependent). Where prices are published, Yucca is the lower-cost option.

Both are cash-pay compounded programs, so the real decision comes down to price, shipping, pharmacy credentials and support rather than the drug itself.

Side by side

Full specs, compared

Yucca
DirectMeds
Why choose itNationwide 50-state licensing with a low entry priceFast shipping and a low entry price, no insurance needed
Watch out forSmaller review base than top programsSmaller, less-established than top programs
Starting priceFrom $146/moFrom $147/mo
Compounded semaglutideCompounded (from ~$146/mo)Compounded (from ~$147/mo)
TirzepatideCompounded (plan-dependent)Compounded (plan-dependent)
GLP-1 + GIP optionYes — compounded tirzepatide (GLP-1/GIP)Yes — compounded tirzepatide (GLP-1/GIP)
Offering typeCompoundedCompounded
New-patient offerVariesVaries
Billing modelMonthly plansMonthly plans
What's includedMedical evaluation, Medication, Expedited shippingOnline medical visit, Medication, Free shipping
Lab workOnline intakeOnline intake
ShippingFree expeditedFree 1–2 day
RefillsMonthly refillsMonthly refills
StatesAll 50 statesMost US states
PharmacyUS compounding pharmaciesUS compounding pharmacies
CliniciansUS-licensed providersUS-licensed prescribers
InsuranceCashCash
ConsultationOnline medical intakeOnline medical visit
Our rating8.1 · Good8.0 · Good

The medicine

Medications & formulations

  • Yucca: compounded GLP-1. Yes — compounded tirzepatide (GLP-1/GIP)
  • DirectMeds: compounded GLP-1. Yes — compounded tirzepatide (GLP-1/GIP)

New to the drugs themselves? Read our plain-language guides to semaglutide, tirzepatide, and the new GLP-1 pills.

The trade-offs

Pros & cons

Yucca logo

Pros

  • Available in all 50 states
  • Free expedited shipping
  • Low entry price

Cons

  • Smaller review base
  • Compounded only
DirectMeds logo

Pros

  • Fast 1–2 day shipping
  • No insurance required
  • Low entry price

Cons

  • Smaller, less-established brand
  • Compounded only

What real DirectMeds customers say

4.6 / 5out of 5

16,390 reviews · checked October 2026

Trustpilot

Verbatim reviews we captured, including every 2-star one.

Sort
Sep 23, 2026

“Thanks to all the help I rec'd from both Chelsea King and Matthew Jakins. Both were very professional, helpful, organized, leading me through all the necessary steps involved in this process. If medication is as helpful as these 2 employees it is a win win situation. I can't believe how patient and kind these 2 individuals were in helping with all the questions and confusion there was on my part ! Thank you again Chelsea and Matthew !!!!”

S

Sandra

US

Sep 23, 2026

“Chelsea King helped me. She was fast took time to listen.”

M

Monica N.

US

Sep 23, 2026

“Signup process was straight forward and easy to navigate. Communication via text and email was almost too much, but nice to have for a new customer”

B

Bryan D.

US

Sep 22, 2026

“Belinda was very good. Answered all my questions very efficiently”

M

Mary Ann R.

US

“A great personnel, you have answering the phone and following up. Plus its a wonderful product”

J

John

US

“Chelsea King was the best customer service representative. She was smart, friendly and helpful. I would definitely recommend her!”

C

Charisse

US

“I spoke with two of your agents and they were extremely helpful. First I spoke with Summer who was delightful and professional. Then I spoke with Leon, who helped me with an order I was having difficulty with. I was extremely pleased with their friendly professionalism and knowledge of the product.”

C

Customer

US

Sep 23, 2026

“The rep was courteous and kind. She addressed my problem and promptly took care of the issue. I believe it was Madison.”

L

Lauren

US

Sep 23, 2026

“Prompt service”

J

Janet G.

US

Sep 22, 2026

“In speaking to your reps I found them very polite and helpful. I appreciated all the help. However, the doc was not very helpful. I couldn't access his message. However, I did get a message that my meds were on the way. Since I am not good at accessing my account, it is probably my fault. I would prefer to speak to your reps rather than go through an on line account.”

T

Toni R.

US

Sep 23, 2026

“I have had a few issues with this company but they came through for me and Im doing really well on my meds. Looking forward to the next few months with them. Reasonable prices as well”

G

Gina

US

Sep 22, 2026

“My first bottle of NAD that I received was 50 mg. I was to take 20 units Monday through Friday. I only had enough medication for two weeks. I then called and requested an increase to 1000 mg of NAD and I am waiting for it to be delivered. I want to be sure that I will receive enough for 30 days. My first batch was only enough supply for two weeks and I was sent no syringes. Are you going to make up for the shortage?”

J

Julia

US

Sep 23, 2026

“I had an order placed since Sep 4th. It did not actually ship until I had called 3 times. It just said "Label Created". The order was damaged in transit and the contents discarded. When I went online to the chat, the AI kept saying the order was delivered. I had to call in and get things straightened out. Now I am waiting for the replacement order to ship.”

J

Jackson J.

US

Reviews are individual experiences quoted verbatim from public Trustpilotprofiles, names shortened; any weight-loss result mentioned is one person’s and is not typical — results vary. We don’t edit or curate them to flatter our pick.

Head to head

Where each one wins

We don't tally a single winner — that hides the trade-offs. Here's who leads on each dimension, and why.

Semaglutide price
Yucca

Yucca: Compounded (from ~$146/mo). DirectMeds: Compounded (from ~$147/mo).

Medication range
Toss-up

Yucca offers compounded; DirectMeds offers compounded.

Shipping
Toss-up

Yucca: Free expedited. DirectMeds: Free 1–2 day.

Pharmacy credentials
Toss-up

Comparable pharmacy disclosures.

Insurance coordination
Toss-up

Both are primarily cash-pay for compounded GLP-1.

Pick fast

Match it to your priority

Find your top priority, see which program we'd point you to.

If your priority is the lowest published price

YuccaYucca lists the lower semaglutide price.

If your priority is the best shipping

YuccaFaster/cheaper shipping.

If your priority is our overall pick

Yuccanationwide 50-state licensing with a low entry price

Questions

Yucca vs DirectMeds: common questions

Where prices are published, Yucca lists the lower semaglutide price (Compounded (from ~$146/mo)). Both may run promotions and change pricing, so confirm current rates on each site.

The bottom line

Yucca is our pick in this matchup — nationwide 50-state licensing with a low entry price. Choose DirectMeds only if its strength (fast shipping and a low entry price, no insurance needed) matters more to you than price and our overall rating.

How we compare — and how to read this

We weigh the factors that actually change a patient’s experience: real price (and whether it’s compounded or branded), the medications and formulations on offer, shipping, pharmacy accreditation and the clinician model, insurance stance, and commitment. We name a top pick for most people, then lay the trade-offs out in full so you can override it when your priorities or insurance point the other way. Pricing is provider-reported and moves often — and compounded-drug availability shifts with FDA shortage status — so confirm the current details on the provider’s own site before enrolling. Affiliate relationships never change a program’s placement. This page is educational, not medical advice; see our disclaimer.

Is Yucca legit? Read the full reviewIs DirectMeds legit? Read the full review