Yucca vs DirectMeds
Yucca and DirectMeds are both telehealth GLP-1 programs, but they differ on price, medications, shipping and how you pay. Here's the side-by-side, with the numbers, so you can pick the right one.
Last reviewed 2026-09-01 · Pricing is provider-reported and changes often — confirm current rates on each provider's site. We may earn a commission.
Educational, not medical advice. This page explains GLP-1 medications in general terms. Only a licensed clinician who knows your history can decide what's right for you.
Yucca is our pick in this matchup — nationwide 50-state licensing with a low entry price. Consider DirectMeds instead if its strength — fast shipping and a low entry price, no insurance needed — matters more to you.
View Plan: YuccaChoose Yucca if…
you want Yucca's edge — nationwide 50-state licensing with a low entry price.
Choose DirectMeds if…
you want DirectMeds's edge — fast shipping and a low entry price, no insurance needed.
Cost breakdown
The numbers that actually decide it, side by side.
| | |
|---|---|---|
| Starting price | From $146/mo | From $147/mo |
| Semaglutide | Compounded (from ~$146/mo) | Compounded (from ~$147/mo) |
| Tirzepatide | Compounded (plan-dependent) | Compounded (plan-dependent) |
| Offering | Compounded | Compounded |
| Shipping | Free expedited | Free 1–2 day |
| Insurance | Cash | Cash |
On price, Yucca lists Compounded (from ~$146/mo) for compounded semaglutide and Compounded (plan-dependent) for tirzepatide, while DirectMeds lists Compounded (from ~$147/mo) and Compounded (plan-dependent). Where prices are published, Yucca is the lower-cost option.
Both are cash-pay compounded programs, so the real decision comes down to price, shipping, pharmacy credentials and support rather than the drug itself.
Full specs, side by side
| | |
|---|---|---|
| Starting price | From $146/mo | From $147/mo |
| Compounded semaglutide | Compounded (from ~$146/mo) | Compounded (from ~$147/mo) |
| Tirzepatide | Compounded (plan-dependent) | Compounded (plan-dependent) |
| GLP-1 + GIP option | Yes — compounded tirzepatide (GLP-1/GIP) | Yes — compounded tirzepatide (GLP-1/GIP) |
| Offering type | Compounded | Compounded |
| New-patient offer | Varies | Varies |
| Billing model | Monthly plans | Monthly plans |
| What's included | Medical evaluation, Medication, Expedited shipping | Online medical visit, Medication, Free shipping |
| Lab work | Online intake | Online intake |
| Shipping | Free expedited | Free 1–2 day |
| Refills | Monthly refills | Monthly refills |
| States | All 50 states | Most US states |
| Pharmacy | US compounding pharmacies | US compounding pharmacies |
| Clinicians | US-licensed providers | US-licensed prescribers |
| Insurance | Cash | Cash |
| Consultation | Online medical intake | Online medical visit |
| Our rating | 8.1 · Good | 8.0 · Good |
Medications & formulations
- Yucca: compounded GLP-1. Yes — compounded tirzepatide (GLP-1/GIP)
- DirectMeds: compounded GLP-1. Yes — compounded tirzepatide (GLP-1/GIP)
New to the drugs themselves? Read our plain-language guides to semaglutide and tirzepatide.
Pros & cons
Pros
- Available in all 50 states
- Free expedited shipping
- Low entry price
Cons
- Smaller review base
- Compounded only
Pros
- Fast 1–2 day shipping
- No insurance required
- Low entry price
Cons
- Smaller, less-established brand
- Compounded only
Where each one has the edge
We don't tally a winner — that hides the trade-offs. Here's who leads on each dimension and why.
Yucca: Compounded (from ~$146/mo). DirectMeds: Compounded (from ~$147/mo).
Yucca offers compounded; DirectMeds offers compounded.
Yucca: Free expedited. DirectMeds: Free 1–2 day.
Comparable pharmacy disclosures.
Both are primarily cash-pay for compounded GLP-1.
Match by your priority
The fastest way to decide: find your top priority, see which program we'd point you to.
If your priority is the lowest published price
If your priority is the best shipping
If your priority is our overall pick
Yucca vs DirectMeds: common questions
The bottom line
Yucca is our pick in this matchup — nationwide 50-state licensing with a low entry price. Choose DirectMeds only if its strength (fast shipping and a low entry price, no insurance needed) matters more to you than price and our overall rating.
How we compare — and how to read this
We compare programs on the factors that actually affect a patient: real price (including whether it's compounded or branded), medications and formulations offered, shipping, pharmacy accreditation and clinician model, insurance stance, and commitment. We name a top pick for most people, but we show the trade-offs in full so you can override it when your priorities or insurance point the other way. Pricing is provider-reported and changes frequently — and compounded-drug availability shifts with FDA shortage status — so always confirm the current details on the provider's own site before enrolling. Affiliate relationships do not change a program's placement. This page is educational and not medical advice; see our disclaimer.